Buy Cialis Tadalafil online

Cialis is a PDE5 inhibitor which is used to cure erectile dysfunction in men. It is sold in pill form.

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Drug Uses

Cialis helps men to achieve and sustain an erection for longer periods while having sexual activities. It is an oral medication. Usage You must always follow your doctor’s dosage instructions while taking Cialis. If you still have any doubts then there will be detailed dosage instructions on the medicine label. Cialis comes in various doses like 5mg, 10mg and 20 mg. The ideal dose for starting with Cialis is 10mg once a day. You need to take it half an hour before sexual activity. Missed Dose You need to take Cialis only before any sexual activity. You cannot take Cialis more than one dose a day. Storage Store Cialis at room temperature. Overdose You must contact your doctor immediately or contact an emergency medical center if you suspect an overdose.

Safety Information

Discuss your past/current medical history in detail with your doctor before beginning treatment with any new medication. If you are using any herbal supplements or over the counter medication, including vitamin pills, then mention it to your doctor.
Please mention to your doctor if you have suffered from or are suffering from medical conditions like using a nitrate drug for chest pain or heart problems.
Doctors advise against using the drug if you are allergic to any ingredient in it or if you are also using a nitrate drug for chest pain or heart problems, including
nitroglycerin (Nitrostat, Nitrolingual, Nitro-Dur, Nitro-Bid, Minitran, Deponit, Transderm-Nitro),
isosorbide dinitrate (Dilatrate-SR, Isordil, Sorbitrate),
isosorbide mononitrate (Imdur, ISMO, Monoket), or recreational drugs such as amyl nitrate or nitrite (“poppers”).

Cialis when taken with a nitrate medicine can cause a serious decrease in blood pressure, leading to fainting, stroke or heart attack. Tell your doctor if you have any of the following conditions before taking tadalafil:
a recent history a heart attack (within the past 90 days);
a recent history of stroke or congestive heart failure (within the past 6 months);
angina (chest pain);
high or low blood pressure;
liver disease;
kidney disease (or if you are on dialysis);
a blood cell disorder such as sickle cell anemia, multiple myeloma, or leukemia;
a bleeding disorder such as hemophilia;
a stomach ulcer;
retinitis pigmentosa (an inherited condition of the eye);
a physical deformity of the penis (such as Peyronies disease); or
if you have been told you should not have sexual intercourse for health reasons.

Active ingredients
Tadalafil
Release form
Tablets
Composition
Active ingredient: tadalafil. Excipients: lactose monohydrate – 109.65 mg; lactose monohydrate (spray dried) 17.5 mg; hyprolosis – 1.22 mg; extra thin hyprolosis – 2.8 mg; sodium lauryl sulfate – 0.49 mg; MCC – 26.25 mg; croscarmellose sodium – 11.2 mg; magnesium stearate (vegetable) – 0.88 mg. Film shell: Opadry yellow (Y-30-12863-A) (lactose monohydrate – 3.72 mg, hypromellose – 2.59 mg, titanium dioxide – 1.54 mg, triacetin – 0.74 mg, iron dye yellow oxide – 0.16 mg) – 8.75 m
Pharmacological effect
Improving erectile function
Pharmacokinetics
The pharmacokinetics of tadalafil in patients with erectile dysfunction is similar to the pharmacokinetics of the drug in patients without erectile dysfunction. Absorption After taking the drug inside, tadalafil is rapidly absorbed. Average Cmax in plasma is achieved on average 2 hours after oral administration. The speed and degree of absorption of tadalafil do not depend on food intake, therefore Cialis can be used regardless of food intake. The time of intake (morning or evening) had no clinically significant effect on the rate and extent of absorption. The pharmacokinetics of tadalafil in healthy individuals is linear with respect to time and dose. In the dose range from 2.5 to 20 mg, AUC increases in proportion to the dose. The distribution of Css in plasma is achieved within 5 days when taking the drug 1 time / day. The average Vd is about 63 liters, which indicates that tadalafil is distributed in body tissues. The plasma protein binding of tadalafil at therapeutic concentrations is 94%. In healthy individuals, less than 0.0005% of the administered dose is found in semen. Metabolism Tadalafil is mainly metabolized with the participation of the CYP3A4 isoenzyme. The main circulating metabolite is methylcatechol glucuronide. This metabolite is at least 13,000 times less active against PDE5 than tadalafil. Therefore, the concentration of this metabolite is not clinically relevant. Excretion In healthy individuals, the average clearance of tadalafil when taken orally is 2.5 l / h, and the average T1 / 2 is 17.5 hours.Tadalafil is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose). Pharmacokinetics in special clinical situations Protein binding is not altered by impaired renal function. Healthy elderly patients (65 years and more) had a lower clearance of tadalafil when taken orally, which was expressed in an increase in AUC by 25% compared to healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment. No dose adjustment is required in patients with mild to moderate renal insufficiency. Due to the increased exposure of tadalafil (AUC), patients with severe renal insufficiency are not recommended to use Cialis. The pharmacokinetics of tadalafil in patients with mild and moderate hepatic impairment is comparable to that in healthy individuals. For patients with severe hepatic impairment (Child-Pugh class C), no data are available. When prescribing Cialis to patients with severe hepatic impairment, it is necessary to first assess the risks and benefits of using the drug. In patients with diabetes mellitus while using tadalafil, the AUC was approximately 19% less than in healthy individuals. This difference does not require dose adjustment.
Indications
Erectile dysfunction
Contraindications
Simultaneous administration of drugs containing any organic nitrates; children and adolescents up to 18 years old; hypersensitivity to tadalafil
Application during pregnancy and lactation
The drug is not used in women
Method of administration and dosage
Inside. The use of the drug Cialis according to the indication is erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of administration is 5 mg daily, 1 time per day, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (less than 2 times a week): it is recommended to prescribe the drug Cialis at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of the drug. The maximum daily dose of Cialis is 20 mg. The use of the drug Cialis according to the indication of BPH or ED / BPH. The recommended dose of the drug Cialis when applied once a day is 5 mg; the drug should be taken at approximately the same time of the day, regardless of the time of sexual activity. The duration of treatment is determined by the doctor individually. In patients with mild renal insufficiency (Cl creatinine from 51 to 80 ml / min) and moderate (Cl creatinine from 31 to 50 ml / min), dose adjustment is not required. In patients with severe renal failure (Cl creatinine <30 ml / min and on hemodialysis):